The chemical industry is a significant contributor to the EU’s economy. It is simultaneously instrumental to the green and digital transition and exposed to its effects. A steady supply of (green) chemicals is required to deploy renewable energy generators, insulate Europe’s building stock and create reusable and recyclable consumer goods. On the other hand, chemical synthesis is an energy-intensive process inherently dependent on carbon-based feedstock (currently derived almost exclusively from fossil fuels). In addition, chemistry is a global industry with international value chains, where the EU both collaborates and competes with other countries for materials, knowledge and skills. Transforming the European chemical industry into a sustainable motor for the green and digital transition will require investments in infrastructure, assets and skills. Focus should be placed on chemicals that are crucial to this Twin Transition, Europe’s resilience, or both. The long lead time required for the deployment of infrastructure and the development of skills means that such investments must be made now to achieve targets set for 2050. In connection with these issues, the report at hand aims to give insights into a number of value chains that are strategic to EU economy. It considers which chemicals and innovations are vital to transforming these value chains as well as rendering them more resilient and future-fit. To this end, a participatory workshop-based foresight approach was implemented to provide a unique set of insights from stakeholders and translate them into actions and policy recommendations.